Establishing An Asphyxial Pulseless Electrical Activity Arrest Model In Rabbits
نویسنده
چکیده
Objective:Pulseless Electrical Activity (PEA) is an increasingly frequent cardiac rhythm in the arrested patient. We determined to establish an intact animal model of asphyxial PEA of variable duration that may be utilized for evaluation of agents of potential benefit in this scenario. Method:Instrumented adult New Zealand White rabbits underwent induction of hypoxic PEA via tracheal cross-clamping. Resuscitation with mechanical ventilation, external chest compressions, and intravenous saline bolus was instituted following 2, 4, and 6 minutes of asphyxial arrest. Adrenaline at 100 mcg/kg was administered at 5 minutes intervals, and DC defibrillation for VT/VF. Coronary perfusion pressure (CPP), mean arterial pressure (MAP), and return of spontaneous circulation (ROSC) were recorded. Results:Time to PEA was 279 +/57 seconds. No difference in CPP prior to ROSC was observed between groups. Seven of 11 (64%) animals exhibited ROSC following 2 minutes cardiac arrest, 3 of 7 (42%) following 4 minutes, and 1 of 6 (17%) following 6 minutes (p=0.065). No difference in MAP following ROSC was observed between groups. Conclusion: We have described a reliable model of asphyxial PEA in rabbits that may be utilized for evaluation of treatments in hypoxic cardiac arrest. Practical suggestions for successful adoption are given.
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تاریخ انتشار 2012